ORIGINAL PAPER
Association of nonalcoholic fatty liver with carotid intima-media thickness in patients with dyslipidaemia
Submission date: 2018-06-27
Final revision date: 2018-08-04
Acceptance date: 2018-09-25
Publication date: 2018-09-30
Medical Studies 2018;34(3):226-231
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults, which is associated with metabolic syndrome.
Aim of the research:
To investigate the association of fatty liver with carotid intima-media thickness (CIMT) in patients with dyslipidaemia.
Material and methods:
Fifty-two patients with uncomplicated NAFLD were enrolled. Sixty-four sex- and aged-match subjects without NAFLD were considered as controls. An ultrasound was performed in the supine and left lateral positions. In all patients, CIMT was measured by high-resolution real-time B-mode ultrasonography with a 7.5-MHz linear transducer. Data, including CIMT, plasma liver function tests, and other biochemical blood measurements, were collected.
Results:
The mean CIMT in cases (0.66 mm) was significantly greater than the controls (0.58 mm) (p = 0.003). The mean CIMT in patients with fatty liver grade III (0.71 mm) was significantly more than the patient with fatty liver grade II (0.65 mm) (p = 0.003). Older age, hypertension, diabetes, body mass index, and smoking were associated with increased CIMT.
Conclusions:
In patients with NAFLD and dyslipidaemia a significant increase in the CIMT has been observed compared to the control. So, it seems that performing liver ultrasound in patients with dyslipidaemia is reasonable, and in the presence of fatty liver, assessment of carotid atherosclerotic changes is recommended, which may lead to therapeutic intervention. Considering ultrasound as a noninvasive and non-ionising radiation imaging technique, as well as its low cost and availability, may make this method an ideal candidate for a diagnosis.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults, which is associated with metabolic syndrome.
Aim of the research:
To investigate the association of fatty liver with carotid intima-media thickness (CIMT) in patients with dyslipidaemia.
Material and methods:
Fifty-two patients with uncomplicated NAFLD were enrolled. Sixty-four sex- and aged-match subjects without NAFLD were considered as controls. An ultrasound was performed in the supine and left lateral positions. In all patients, CIMT was measured by high-resolution real-time B-mode ultrasonography with a 7.5-MHz linear transducer. Data, including CIMT, plasma liver function tests, and other biochemical blood measurements, were collected.
Results:
The mean CIMT in cases (0.66 mm) was significantly greater than the controls (0.58 mm) (p = 0.003). The mean CIMT in patients with fatty liver grade III (0.71 mm) was significantly more than the patient with fatty liver grade II (0.65 mm) (p = 0.003). Older age, hypertension, diabetes, body mass index, and smoking were associated with increased CIMT.
Conclusions:
In patients with NAFLD and dyslipidaemia a significant increase in the CIMT has been observed compared to the control. So, it seems that performing liver ultrasound in patients with dyslipidaemia is reasonable, and in the presence of fatty liver, assessment of carotid atherosclerotic changes is recommended, which may lead to therapeutic intervention. Considering ultrasound as a noninvasive and non-ionising radiation imaging technique, as well as its low cost and availability, may make this method an ideal candidate for a diagnosis.
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| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
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