Deep neck abscesses of non-odontogenic origin are characterised by different microbiological and clinical manifestations. Based on clinical presentations, the possible complications and results of different methods of treatment were described. We present five cases of non-odontogenic deep neck infections. Computed tomography was used to confirm the diagnosis and monitor the treatment’s effectiveness. In three cases, the cause of infection was unidentified, while in the remaining cases pharyngitis and sialoadenitis were non-odontogenic causes of infection. Usually the causative flora were not identified, but in the remaining cases Streptococcus anginosus and Eschericha coli predominated. Computed tomography is the most recommended diagnostic method to detect infection and monitor its progression and treatment. The choice of surgical approach depends on the location of the abscess and its progression. Empirical antibiotic therapy provides additional medical support and complements surgical treatment. Diabetes is an important predisposing factor of deep neck infections.