REVIEW PAPER
Degenerative cervical spine disease – pathogenesis and symptoms
1
Department of Neurosurgery and Spine Surgery, Regional Hospital, Kielce, Poland
2
Department of Neurosurgery, Spine Surgery and Peripheral Nerves, University Clinical Hospital Military Medical Academy – Central Veterans Hospital, Lodz, Poland
Submission date: 2020-09-10
Final revision date: 2020-11-23
Acceptance date: 2020-11-23
Publication date: 2020-12-31
Medical Studies 2020;36(4):310-315
KEYWORDS
TOPICS
ABSTRACT
Cervical discopathy is a degenerative process in the intervertebral disc and the structure of the fibrous ring. Due to the processes of proteoglycan breakdown and collagen structure, the nucleus pulposus is dehydrated and susceptible to the damaging process. The stretching of the ring leads to its tearing and the appearance of a hernia of the nucleus pulposus. These changes lead to the growth of degeneration in the anatomical structures, i.e. the yellow ligament or intervertebral joints. Treatment of the disease should take into account the mechanism of degeneration and biomechanics of the cervical spine.
REFERENCES (24)
1.
Martirosyan NL, Patel AA, Carotenuto A, Yashar M, Kalani S, Belykh E, Walker CT, Preul MC, Theodore N. Genetic alterations in intervertebral disc disease. Front Surg 2016; 3: 59.
2.
Ferrara LA. The biomechanics of cervical spondylosis. Adv Orthop 2012; 2012: 493605.
3.
Hadjipavlou AG, Tzermiadianos MN, Bogduk N, Zindrick MR. The pathophysiology of disc degeneration. J Bone Joint Surg Br 2008; 90: 1261-1270.
4.
Cheung KM, Chan D, Karppinen J, Chen Y, Jim JJ, Yip SP, Ott J, Wong KK, Sham P, Luk KD, Cheah KS, Leong JC, Song YQ. Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 2006; 31: 1143-1148.
5.
Annunen S, Paassilta P, Lohiniva J, Perälä M, Pihlajamaa T, Karppinen J, Tervonen O, Kröger H, Lähde S, Vanharanta H, Ryhänen L, Göring HH, Ott J, Prockop DJ, Ala-Kokko L. An allele of COL9A2 associated with intervertebral disc disease. Science 1999; 285: 409-412.
6.
Eser B, Cora T, Eser O, Kalkan E, Haktanir A, Erdogan MO, Solak M. Association of the polymorphisms of vitamin D receptor and aggrecan genes with degenerative disc disease. Genet Test Mol Biomarkers 14: 313-317.
7.
Guo TM, Liu M, Zhang YG, Guo WT, Wu S. Association between caspase-9 promoter region polymorphisms and discogenic low back pain. Connect Tissue Res 2011; 52: 133-138.
8.
Mullin J, Shedid D, Benzel E. Overview of cervical spondylosis pathophysiology and biomechanics. WScJ 2011; 2: 89-97.
9.
Matsumoto M, Fujimura Y, Suzuki N, Nishi Y, Nakamura M, Yabe Y, Shiga H.Matsumoto M1, Fujimura Y, Suzuki N, Nishi Y, Nakamura M, Yabe Y, Shiga H. MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Jt Surg Br 1998; 80: 19-24.
10.
Kelly JC, Groarke PJ, Butler JS, Poynton AR, O’Byrne JM. The natural history and clinical syndromes of degenerative cervical spondylosis. Adv Orthop 2012; 2012: 393642.
11.
Peng B, DePalma MJ. Cervical disc degeneration and neck pain. J Pain Res 2018; 11: 2853-2857.
12.
Murata Y, Onda A, Rydevik B, Takahashi I, Takahashi K, Olmarker K. Changes in pain behavior and histologic changes caused by application of tumor necrosis factor-alpha to the dorsal root ganglion in rats. Spine 2006; 31: 530-535.
14.
Davies BM, Mowforth OD, Smith EK, Kotter MR. Degenerative cervical myelopathy. BMJ 2018; 360: k186.
15.
Sureka B, Mittal A, Mittai MK, Agarwal K, Sinha M, Thukral BB. Morphometric analysis of cervical spinal canal diameter, transverse foramen, and pedicle width using computed tomography in Indian population. Neurol India 2018; 66: 454-458.
16.
Kaiser MG, Mummaneni PV, Matz PG, Anderson PA, Groff MW, Heary RF, Holly LT, Ryken TC, Choudhri TF, Vresilovic EJ. Radiographic assessment of cervical subaxial fusion. J Neurosurg Spine 2009; 11: 221-227.
17.
Fernandez de Rota JJ, Meschian S, de Rota AF, Urbano V, Baron M. Cervical spondylotic myelopathy due to chronic compression: the role of signal intensity changes in magnetic resonance images. J Neurosurg Spine 2007; 6: 17-22.
18.
Holly LT, Matz PG, Anderson PA, Groff MW, Heary RF, Kaiser MG, Mummaneni PV, Ryken TC, Choudhri TF, Vresilovic EJ, Resnick DK. Clinical prognostic indicators of surgical outcome in cervical spondylotic myelopathy. J Neurosurg Spine 2009; 11: 112-118.
19.
Overley SC, Merrill RK, Baird EO, Meaike JJ, Cho SK, Hecht AC, Qureshi SA. Is cervical bracing necessary after one- and two-level instrumented anterior cervical discectomy and fusion? A prospective randomized study. Global Spine J 2018; 8: 40-46.
20.
McAllister BD, Rebholz BJ, Wang JC. Is posterior fusion necessary with laminectomy in the cervical spine? Surg Neurol Int 2012; 3 (Suppl 3): S225-S231.
21.
Cossu G, Messerer M, Barges-Coll J. Cervical posterior foraminotomy: how I do it. Acta Neurochir 2020; 162: 675-678.
22.
Otani K, Iwabuchi M, Sato K, Konno S, Kikuchi S. Postoperative neck symptoms of posterior approach for cervical compressive myelopathy: expansive open-door laminoplasty vs. segmental partial laminectomy. Fukushima J Med Sci 2018; 64: 54-59.
23.
O’Connor A, George JW, Thompson PA, Nelson DM, Skaggs C, Gross G. The stabilizing system of the spine and comprehensive modern approaches to back pain. Int Musculoskelet Med 2012; 34: 42-54.
24.
Razzaq A, Sajjad AG, Yasin S, Tariq R, Ashraf FJ. Comparison of Cyriax manipulation with traditional physical therapy for the management of cervical discogenic problems. A randomized control trial. Pak Med Assoc 2020; 70: 1329-1333.
| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
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