REVIEW PAPER
Sublingual and subcutaneous allergen-specific immunotherapy as
a method of treatment of patients with inhalant allergy – a review
of the literature
1
Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Lublin, Poland
Submission date: 2021-03-20
Final revision date: 2021-04-26
Acceptance date: 2021-05-24
Publication date: 2021-09-22
Medical Studies 2021;37(3):250-257
KEYWORDS
TOPICS
ABSTRACT
Allergy is the result of the body’s intolerance to harmless antigens. In the treatment of respiratory allergies, allergen immunotherapy (AIT) is a causal method of treating allergies. It can be carried out via the subcutaneous route (SCIT) or the sublingual route (SLIT) – in the form of drops or tablets. Desensitisation is recommended from the age of 5 years, and the doses of the drug should be repeated gradually so that the body acquires immunological tolerance to allergens. Thirty-six current publications from the PubMed and Google Scholar platforms were reviewed. A series of studies confirming the safety, efficacy, and good tolerability of both types of AIT in children and adults were referred to. The results presented in the review show the similarities and differences between the desensitisation methods. They differ, among other things, in the convenience of use, the price, the frequency of side effects of treatment, and the dosage.
REFERENCES (37)
1.
Bacher P, Scheffold A. Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy. Mucosal Immunol 2018; 11: 1537-1550.
2.
Marwa K, Kondamudi NP. Type IV hypersensitivity reaction. In: StatPearls. Treasure Island (FL): StatPearls Publishing; March 7, 2021.
3.
Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, Halken S, Larenas-Linnemann D, Pawankar R, Pitsios C, Sheikh A, Worm M, Arasi S, Calderon MA, Cingi C, Dhami S, Fauquert JL, Hamelmann E, Hellings P, Jacobsen L, Knol EF, Lin SY, Maggina P, Mös-ges R, Oude Elberink JNG, Pajno GB, Pastorello EA, Penagos M, Rotiroti G, Schmidt-Weber CB, Timmermans F, Tsilochristou O, Varga EM, Wilkinson JN, Williams A, Zhang L, Agache I, Angier E, Fernandez-Rivas M, Jutel M, Lau S, van Ree R, Ryan D, Sturm GJ, Muraro A. EAACI Guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy 2018; 73: 765-798.
4.
Mortuaire G, Michel J, Papon JF, Malard O, Ebbo D, Crampette L, Jankowski R, Coste A, Serrano E. Specific immunotherapy in allergic rhinitis. Eur Ann Otorhinolaryngol Head Neck Dis 2017; 134: 253-258.
5.
Gunawardana NC, Zhao Q, Carayannopoulos LN, Tsai K, Malkov VA, Selverian D, Clarke G, Mant T, Butts BD, Lund K, Hansel TT, Nolte H. The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms. J Allergy Clin Immunol 2018; 141: 785-788.
6.
Creticos PS. Allergen immunotherapy: vaccine modification. Immunol Allergy Clin North Am 2016; 36: 103-124.
7.
Nolte H, Maloney J. The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases. Allergol Int 2018; 67: 301-308.
8.
Hur GY, Lee JH, Park HS. Allergen immunotherapy for the treatment of respiratory allergies in the elderly. Curr Opin Allergy Clin Immunol 2017; 17: 304-308.
9.
Pfaar O, Lou H, Zhang Y, Klimek L, Zhang L. Recent developments and highlights in allergen immunotherapy. Allergy 2018; 73: 2274-2289.
10.
Eguiluz-Gracia I, Ariza A, Testera-Montes A, Rondón C, Campo P. Allergen immunotherapy for local respiratory allergy. Curr Allergy Asthma Rep 2020; 20: 23.
11.
Klimek L, Mosbech H, Zieglmayer P, Rehm D, Stage BS, Demoly P. SQ house dust mite (HDM) SLIT-tablet provides clinical improvement in HDM-induced allergic rhinitis. Expert Rev Clin Immunol 2016; 12: 369-377.
12.
Penagos M, Durham SR. Duration of allergen immunotherapy for inhalant allergy. Curr Opin Allergy Clin Immunol 2019; 19: 594-605.
13.
Muraro A, Roberts G, Halken S, Agache I, Angier E, Fernandez-Rivas M, Gerth van Wijk R, Jutel M, Lau S, Paj-.
14.
no G, Pfaar O, Ryan D, Sturm GJ, van Ree R, Varga EM, Bachert C, Calderon M, Canonica GW, Durham SR, Malling HJ, Wahn U, Sheikh A. EAACI guidelines on allergen immunotherapy: executive statement. Allergy 2018; 73: 739-743.
15.
Masuyama K, Okamoto Y, Okamiya K, Azuma R, Fujinami T, Riis B, Ohashi-Doi K, Natsui K, Imai T, Okubo K. Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet in Japanese children. Allergy 2018; 73: 2352-2363.
16.
Brunton S, Nelson HS, Bernstein DI, Lawton S, Lu S, Nolte H. Sublingual immunotherapy tablets as a disease-modifying add-on treatment option to pharmacotherapy for allergic rhinitis and asthma. Postgrad Med 2017; 129: 581-589.
17.
Didier A, Malling HJ, Worm M, Horak F, Sussman GL. Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score. Clin Transl Allergy 2015; 5: 12.
18.
Biedermann T, Kuna P, Panzner P, Valovirta E, Anders-son M, de Blay F, Thrane D, Jacobsen SH, Stage BS, Winther L. The SQ tree SLIT-tablet is highly effective and well tolerated: results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol 2019; 143: 1058-1066.
19.
Okamoto Y, Fujieda S, Okano M, Hida H, Kakudo S, Masuyama K. Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: a randomized trial in a pediatric population. Pediatr Allergy Immunol 2019; 30: 66-73.
20.
Demoly P, Emminger W, Rehm D, Backer V, Tommerup L, Kleine-Tebbe J. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol 2016; 137: 444-451.
21.
Zhong C, Yang W, Li Y, Zou L, Deng Z, Liu M, Huang X. Clinical evaluation for sublingual immunotherapy with Dermatophagoides farinae drops in adult patients with allergic asthma. Ir J Med Sci 2018; 187: 441-446.
22.
Tang LX, Yang XJ, Wang PP, Ge WT, Zhang J, Guo YL, Lu J, Tai J, Zhang YM, Ni X. Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis. Allergol Immunopathol 2018; 46: 107-111.
23.
Tankersley M, Han JK, Nolte H. Clinical aspects of sublingual immunotherapy tablets and drops. Ann Allergy Asthma Immunol 2020; 124: 573-582.
24.
Jerzynska J, Stelmach W, Majak P, Stelmach R, Janas A, Stelmach I. Comparison of the effect of 5-grass pollen sublingual immunotherapy tablets and drops in children with rhinoconjunctivitis. Allergy Asthma Proc 2018; 39: 66-73.
25.
Mösges R, Bachert C, Panzner P, Calderon MA, Haazen L, Pirotton S, Wathelet N, Durham SR, Bonny MA, Legon T, von Frenckell R, Pfaar O, Shamji MH. Short course of grass allergen peptides immunotherapy over 3 weeks reduces seasonal symptoms in allergic rhinoconjunctivitis with/without asthma: a randomized, multicenter, double-blind, placebo-controlled trial. Allergy 2018; 73: 1842-1850.
26.
Huang Y, Wang C, Cao F, Zhao Y, Lou H, Zhang L. Comparison of long-term efficacy of subcutaneous immunotherapy in pediatric and adult patients with allergic rhinitis. Allergy Asthma Immunol Res 2019; 11: 68-78.
27.
Bożek A, Kołodziejczyk K, Jarząb J. Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis. Ann Allergy Asthma Immunol 2018; 120: 53-58.
28.
Rondón C, Campo P, Salas M, Aranda A, Molina A, González M, Galindo L, Mayorga C, Torres MJ, Blanca M.Efficacy and safety of D. pteronyssinus immunotherapy in local allergic rhinitis: a double-blind placebo-controlled clinical trial. Allergy 2016; 71 1057-1061.
29.
Rondón C, Blanca-López N, Campo P, Mayorga C, Jurado-Escobar R, Torres MJ, Canto G, Blanca M. Specific immunotherapy in local allergic rhinitis: a randomized, double-blind placebo-controlled trial with Phleum pratense subcutaneous allergen immunotherapy. Allergy 2018; 73: 905-915.
30.
Bożek A, Kołodziejczyk K, Kozłowska R, Canonica GW. Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial. Clin Transl Allergy 2017; 7: 43.
31.
Guan K, Liu B, Wang M, Li Z, Chang C, Cui L, Wang RQ, Wen LP, Leung PSC, Wei JF, Sun JL. Principles of allergen immunotherapy and its clinical application in China: contrasts and comparisons with the USA. Clin Rev Allergy Immunol 2019; 57: 128-143.
32.
Jutel M, Bartkowiak-Emeryk M, Bręborowicz A, Cichocka-Jarosz E, Emeryk A, Gawlik R, Gonerko P, Rogala B, Nowak-Węgrzyn A, Samoliński B; IT Section, PTA. Sublingual immunotherapy (SLIT) – indications, mechanism, and efficacy: position paper prepared by the Section of Immunotherapy, Polish Society of Allergy. Ann Agric Environ Med 2016; 23: 44-53.
33.
Kowalski ML. Wskazania do immunoterapii alergenowej – algorytm kwalifikacji. Pol J Allergol 2018; 5: 129-132.
34.
Tsabouri S, Mavroudi A, Feketea G, Guibas GV. Subcutaneous and sublingual immunotherapy in allergic asthma in children. Front Pediatr 2017; 5: 82.
35.
Rodríguez Del Río P, Vidal C, Just J, Tabar AI, Sanchez-Machin I, Eberle P, Borja J, Bubel P, Pfaar O, Demoly P, Calderón MA. The European survey on adverse systemic reactions in allergen immunotherapy (EASSI): a paediatric assessment. Pediatr Allergy Immunol 2017; 28: 60-70.
36.
Gocki J, Bartuzi Z. Wytyczne/zalecenia. Podskórna i podjęzykowa droga stosowania immunoterapii alergenowej. Schematy leczenia. Pol J Allergol 2018; 5: 137-144.
37.
Kowal J. Strategia leczenia chorób współistniejących a decyzja o immunoterapii alergenowej. Pol J Allergol 2018; 5: 157-162.
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| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
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