REVIEW PAPER
Urinary tract infections: epidemiological and clinical aspects
More details
Hide details
1
Department of Laboratory Diagnostics, Mazovian Specialist Hospital Ltd, Radom, Poland
2
Faculty of Health Sciences, Warsaw Medical Academy, Warsaw, Poland
3
Department of Laboratory Diagnostics, Military Institute of Medicine National Research Institute, Warsaw, Poland
Submission date: 2023-08-30
Final revision date: 2023-11-24
Acceptance date: 2023-12-05
Publication date: 2024-06-29
Corresponding author
Zuzanna Trześniewska-Ofiara
Zuzanna Trześniewska-Ofiara
Department of Laboratory Diagnostics
Mazovian Specialist Hospital Ltd
Radom, Poland
Medical Studies 2024;40(2):208-215
KEYWORDS
TOPICS
ABSTRACT
Urinary tract infections are one of the most common infections affecting outpatients and hospital patients. They are believed to affect 150 million people annually and can present as an asymptomatic infection or infections of varying course and location. Patients most often present with symptoms of dysuria or increased frequency of urination. Urinary tract infections can be divided into lower and upper urinary tract infections, and the most common aetiological agents are Enterobacterales bacilli such as: Escherichia coli, Proteus spp., Klebsiella spp., Enterobacter spp., and Gram-positive cocci Enterococcus spp., Streptococcus agalactiae, and Staphylococcus saphrophyticus. Urinary tract diseases are a major public health burden, and significantly affect the quality of life of affected individuals. The choice of antibiotic and dosage should take into account the patient’s health status, the effectiveness of the drug, along with its side effects.
REFERENCES (48)
1.
Bermingham SL, Ashe JF. Systematic review of the impact of urinary tract infections on health-related quality of life. BJU Int. 2012 Dec; 110(11 Pt C): E830-E836.
2.
Szmulik M, Trześniewska-Ofiara Z, Mendrycka M, Woźniak-Kosek A. A novel approach to screening and managing the urinary tract infections suspected sample in the general human population. Front Cell Infect Microbiol. 2022 Aug; 12: 915288.
3.
Wagenlehner FME, Bjerklund Johansen TE, Cai T, Koves B, Kranz J, Pilatz A, Tandogdu Z. Epidemiology, definition and treatment of complicated urinary tract infections. Nat Rev Urol. 2020 Oct; 17(10): 586-600.
4.
Dzierżanowska D, Bucki R, Durnaś B, Grzybowski JK, Semczuk K, Kasztelewicz B, Żak-Puławska Z. Antybiotykoterapia praktyczna. Alfa Medica Press, Bielsko-Biała 2018; 59-83.
5.
Trześniewska-Ofiara Z, Mendrycka M, Cudo A, Szmulik M, Woźniak-Kosek A. Hospital urinary tract infections in healthcare units on the example of Mazovian Specialist Hospital Ltd. Front Cell Infect Microbiol. 2022 Jul; 12: 891796.
6.
Walters MS, Lane MC, Vigil PD, Smith SN, Walk ST, Mobley HL. Kinetics of uropathogenic Escherichia coli metapopulation movement during urinary tract infection. MBio. 2012 Jan-Feb; 3(1): e00303-11.
7.
Bochniewska V, Jung A, Żuber J. Zakażenie układu moczowego u dzieci. Pediatr Med Rodz. 2012; 1(8): 12-22.
8.
Ross J, Hickling D. Medical treatment for urinary tract infections. Urol Clin North Am. 2022 May; 49(2): 283-297.
9.
Rowe TA, Juthani-Mehta M. Urinary tract infection in older adults. Aging Health. 2013 Oct; 9(5): 519-528.
10.
Duława J. Zakażenia układu moczowego jako problem interdyscyplinarny. Podręcznik dla lekarzy i pielęgniarek. Śląski Uniwersytet Medyczny w Katowicach, Katowice 2022; 75.
11.
Toczek-Wasiak A, Salata B, Dzierżanowski T. Zakażenia układu moczowego w opiece paliatywnej. Med Paliat. 2022; 14(1): 1-10.
12.
Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015 May; 13(5): 269-284.
13.
Kołwzan B. Analiza zjawiska biofilmu-warunki jego powstawania i funkcjonowania. Ochrona Środowiska 2011; 33(4): 3-14.
14.
Łyszcz M. Biofilm-złożona i wielokomórkowa struktura bakterii. In: Badania i Rozwój Młodych Naukowców w Polsce – mikrobiologia i ekologia. Młodzi Naukowcy, I Gleboznawstwa-Państwowy Instytut Uprawy Nawożenia, Poznań 2020; 54-60.
15.
Strużycka I, Stępień I. Biofilm-nowy sposób rozumienia mikrobiologii. Nowa Stomatol. 2009; 3: 85-89.
16.
Ackerman AL, Chai TC. The bladder is not sterile: an update on the urinary microbiome. Curr Bladder Dysfunct Rep. 2019; 4(4): 331-341.
17.
Neugent ML, Hulyalkar NV, Nguyen VH, Zimmern PE, De Nisco NJ. Advances in understanding the human urinary microbiome and its potential role in urinary tract infection. MBio. 2020 Apr; 11(2): e00218-20.
18.
Geerlings SE. Clinical presentations and epidemiology of urinary tract infections. Microbiol Spectr. 2016 Oct; 4(5): 4-5.
19.
Michno M, Sydor A. Urinary tract infections in adults. Przegl Lek. 2016; 73(7): 504-508.
20.
Chmielewska SJ, Fiedoruk K, Daniluk T, Sciepuk M, Kaczmarzyk D, Leszczynska K. Znaczenie uropatogennych szczepów Escherichia coli (UPEC) w etiopatogenezie zakażeń układu moczowego. Post Mikrob. 2016; 55(1): 45-56.
21.
Żurowska A, Wasilewska A, Jung A, Kiliś-Pstrusińska K, Pańczyk-Tomaszewska M, Sikora P, Tkaczyk M, Zagożdżon I. Zalecenia Polskiego Towarzystwa Nefrologii Dziecięcej (PTNFD) dotyczące postępowania z dzieckiem z zakażeniem układu moczowego. Forum Med Rodz. 2016; 10(4): 159-178.
22.
Bulanda M, Wójkowska-Mach J. Zakażenia szpitalne w jednostkach opieki zdrowotnej. Wydawnictwo Lekarskie PZWL, Warszawa 2016.
23.
Szarek K, Kabała M, Martirosian G. Wpływ higieny rąk personelu medycznego na transmisję czynników etiologicznych zakażeń związanych z opieką zdrowotną. Post Mikrob. 2021; 60(4): 309-315.
24.
Babska K. Prewencja zakażeń układu moczowego u pacjentów z cewnikiem moczowym. Forum Nefrol. 2020; 13(2): 98-102.
25.
Holecki M, Hryniewicz W, Pawlik K, Wanke-Rytt M, Duława J, Imiela J, Klinger M. Rekomendacje diagnostyki, terapii i profilaktyki zakażeń układu moczowego u dorosłych. Narodowy Instytut Leków, Warszawa 2015.
26.
Öztürk R, Murt A. Epidemiology of urological infections: a global burden. World J Urol. 2020 Nov; 38(11): 2669-2679.
27.
May M, Schostak M, Lebentrau S, MR2- study group. Guidelines for patients with acute uncomplicated cystitis may not be a paper tiger: a call for its implementation in clinical routine. Int Urogynecol J. 2019 Feb; 30(2): 335-336.
28.
Klein RD, Hultgren SJ. Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies. Nat Rev Microbiol. 2020 Apr; 18(4): 211-226.
29.
Hatfield KM, Dantes RB, Baggs J, Sapiano MRP, Fiore AE, Jernigan JA, Epstein L. Assessing variability in hospital-level mortality among U.S. Medicare beneficiaries with hospitalizations for severe sepsis and septic shock. Crit Care Med. 2018 Nov; 46(11): 1753-1760.
30.
Bono MJ, Leslie SW, Reygaert WC, Doerr C. Urinary tract infection (Nursing). Study Guide from StatPearls Publishing, Treasure Island (FL), 2023.
31.
Peck J, Shepherd JP. Recurrent urinary tract infections: diagnosis, treatment, and prevention. Obstet Gynecol Clin North Am. 2021 Sep; 48(3): 501-513.
32.
Van Decker SG, Bosch N, Murphy J. Catheter-associated urinary tract infection reduction in critical care units: a bundled care model. BMJ Open Qual. 2021 Dec; 10(4): e001534.
33.
Millner R, Becknell B. Urinary tract infections. Pediatr Clin North Am. 2019 Feb; 66(1): 1-13.
34.
Waller TA, Pantin SAL, Yenior AL, Pujalte GGA. Urinary tract infection antibiotic resistance in the United States. Prim Care. 2018 Sep; 45(3): 455-466.
35.
Jung C, Brubaker L. The etiology and management of recurrent urinary tract infections in postmenopausal women. Climacteric. 2019 Jun; 22(3): 242-249.
36.
Urinary tract infection; Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP), 2021; Available at:
https://www.cdc.gov/ncezid/dhq....
37.
Gupta K, Grigoryan L, Trautner B. Urinary tract infection. Ann Intern Med. 2017 Oct; 167(7): ITC49-ITC64.
38.
Kaur R, Kaur R. Symptoms, risk factors, diagnosis and treatment of urinary tract infections. Postgrad Med J. 2021 Dec; 97(1154): 803-812.
39.
Wawrysiuk S, Naber K, Rechberger T, Miotla P. Prevention and treatment of uncomplicated lower urinary tract infections in the era of increasing antimicrobial resistance-non-antibiotic approaches: a systemic review. Arch Gynecol Obstet. 2019 Oct; 300(4): 821-828.
40.
Legaria MC, Barberis C, Famiglietti A, De Gregorio S, Stecher D, Rodriguez CH, Vay CA. Urinary tract infections caused by anaerobic bacteria. Utility of anaerobic urine culture. Anaerobe. 2022 Dec; 78: 102636.
41.
Meena P, Bhargava V, Rana DS, Bhalla AK. Urinary tract infection in renal transplant recipient: A clinical comprehensive review. Saudi J Kidney Dis Transpl. 2021 Mar-Apr; 32(2): 307-317.
42.
Odabasi Z, Mert A. Candida urinary tract infections in adults. World J Urol. 2020 Nov; 38(11): 2699-2707.
43.
Alfouzan WA, Dhar R. Candiduria: evidence-based approach to management, are we there yet? J Mycol Med. 2017 Sep; 27(3): 293-302.
44.
Mattoo TK, Shaikh N, Nelson CP. Contemporary management of urinary tract infection in children. Pediatrics. 2021 Feb; 147(2): e2020012138.
45.
Grabe M, Bartoletti R, Bjerklund Johansen TE, Cai T, Çek M, Köves B, Naber KG, Pickard RS, Tenke P, Wagenlehner F, Wult B. Rekomendacje dotyczące postępowania w zakażeniach układu moczowego. Postępy Andrologii Online. 2017; 4(1): 36-108.
46.
Hryniewicz W, Kuch A, Wanke-Rytt M, Żukowska A. Pałeczki Enterobacterales wytwarzające karbapenemazy (CPE). Epidemiologia, diagnostyka, leczenie i profilaktyka zakażeń. Narodowy Instytut Leków, Warszawa 2022.
47.
Gbinigie OA, Spencer EA, Heneghan CJ, Lee JJ, Butler CC. Cranberry extract for symptoms of acute, uncomplicated urinary tract infection: a systematic review. Antibiotics (Basel). 2021 Jan; 10(1): 12.
48.
Barea BM, Veeratterapillay R, Harding C. Nonantibiotic treatments for urinary cystitis: an update. Curr Opin Urol. 2020 Nov; 30(6): 845-852.