CASE REPORT
Hypereosinophilic syndromes (HES) – different possible faces – a challenge for doctors of various specialisations. Case-based review
1
Faculty of Medicine and Health Sciences,, Jan Kochanowski University, Kielce, Poland
2
Healthcare Team, Włoszczowa, Poland
3
Rheumatology Department, The John Paul III District Hospital, Włoszczowa, Poland
4
Social Academy of Sciences, Collegium Medicum, Lodz, Poland
Submission date: 2023-10-15
Acceptance date: 2023-11-24
Publication date: 2025-04-15
Corresponding author
Małgorzata A. Czarny-Działak
Małgorzata A. Czarny-Działak Faculty of Medicine and Health Sciences Jan Kochanowski University Kielce, Poland
Małgorzata A. Czarny-Działak Faculty of Medicine and Health Sciences Jan Kochanowski University Kielce, Poland
Medical Studies 2025;41(3):292-296
KEYWORDS
TOPICS
ABSTRACT
For practical purposes, acquired eosinophilia can be divided into secondary, clonal, and idiopathic eosinophilia. The causes of secondary eosinophilia may be parasitic infections, allergic diseases, vasculitis, drug reactions, and lymphomas. Hypereosinophilic syndrome (HES) is a subcategory of essential eosinophilia. The diagnosis of idiopathic eosinophilia means that secondary and clonal eosinophilia have been excluded. The aim of this study was to present cases of patients with HES, showing the possible differentiation of organ involvement, which translates into various possible courses of HES. After analysing data from the literature on the clinical course of HES in our patients, we concluded that hypereosinophilic HES syndromes constitute a challenge for physicians of various specialisations. The common denominator connecting all cases will always be an increased number of eosinophilia and a good clinical response to anti-IL-5 antibody treatment.
REFERENCES (23)
1.
Tefferi A, Gotlib J, Pardanani A. Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update. Mayo Clin Proc. 2010; 85(2): 158-164.
2.
Tefferi A, Patnaik MM, Pardanani A. Eosinophilia: secondary, clonal and idiopathic. Br J Haematol. 2006; 133(5): 468-492.
3.
Meltzer E, Percik R, Shatzkes J, Shatzkes J, Sidi Y, Schwartz E. Eosinophilia among returning travelers: a practical approach. Am J Trop Med Hyg. 2008; 78(5): 702-709.
4.
Ganeva M, Gancheva T, Lazarova R, Troeva J, Baldaranov I, Vassilev I, Hristakieva E, Tzaneva V. Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. Int J Dermatol. 2008; 47(8): 853-860.
5.
Campos LE, Pereira LF. Pulmonary eosinophilia. J Bras Pneumol. 2009; 35(6): 561-573.
6.
Méndez-Sánchez N, Chávez-Tapia NC, Vazquez-Elizondo G, Uribe M. Eosinophilic gastroenteritis: a review. Dig Dis Sci. 2007; 52(11): 2904-2911.
7.
Swoger JM, Weiler CR, Arora AS. Eosinophilic esophagitis: is it all allergies? Mayo Clin Proc. 2007; 82(12): 1541-1549.
8.
Seybolt LM, Christiansen D, Barnett ED. Diagnostic evaluation of newly arrived asymptomatic refugees with eosinophilia. Clin Infect Dis. 2006; 42(3): 363-367.
9.
Lassmann B, Tsigrelis C, Virk A. 33-year-old woman with marked eosinophilia. Mayo Clin Proc. 2007; 82(1): 103-106.
10.
Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008; 22(1): 14-22.
11.
Chang HW, Leong KH, Koh DR, Lee SH. Clonality of isolated eosinophils in the hypereosinophilic syndrome. Blood. 1999; 93: 1651-1657.
12.
Gleich GJ, Leiferman KM. The hypereosinophilic syndromes: current concepts and treatments. Br J Haematol. 2009; 145: 271-285.
13.
Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007; 2: 37.
14.
Rosenberg CE, Fulkerson PC, Williams KW. Diagnosis and management of pediatric hypereosinophilic syndrome. J Allergy Clin Immunol Pract. 2022; 10(5): 1131-1138.
15.
Noh HR, Magpantay GG. Hypereosinophilic syndrome. Allergy Asthma Proc. 2017; 38(1): 78-81.
16.
Ionescu MA, Wang L, Janin A. Hypereosinophilic syndrome and proliferative diseases. Acta Dermatovenerol Croat. 2009; 17(4): 323-330,.
17.
Curtis C, Ogbogu P. Hypereosinophilic syndrome. Clin Rev Allergy Immunol. 2016; 50(2): 240-251.
18.
Klion A. Hypereosinophilic syndrome: approach to treatment in the era of precision medicine. Hematology Am Soc Hematol Educ Program. 2018; 2018(1): 326331.
19.
Rosenberg CE, Fulkerson PC, Williams KW. Diagnosis and management of pediatric hypereosinophilic syndrome. J Allergy Clin Immunol Pract. 2022; 10: 1131-1138.
21.
Salih M, Ibrahim R, Tirunagiri D, Al-Ani H, Ananthasubramaniam K. Loeffler’s endocarditis and hypereosinophilic syndrome. Cardiol Rev. 2021; 29(3): 150-155.
22.
Schirmer JH, Hoyer BF. Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia. Z Rheumatol. 2019; 78: 322-332.
23.
Poręba M, Rostoff P, Konduracka E, Pikul P, Rucińska M, Pasowicz M, Piwowarska W. Choroba endomiokardialna jako pierwsza manifestacja zespołu hipereozynofilowego. Kardiol Pol. 2010; 68: 440-445.
| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
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