REVIEW PAPER
The role of bisphenol A in the carcinogenesis process
Submission date: 2018-07-04
Final revision date: 2018-09-10
Acceptance date: 2018-09-28
Publication date: 2018-09-30
Medical Studies 2018;34(3):246-251
KEYWORDS
TOPICS
ABSTRACT
Bisphenol A (BPA), one of the most common endocrine disrupting chemicals, is a carbon-based synthetic compound used in the production of water bottles, cans, food packaging, dental materials, medical equipment, thermal paper, toys and articles for children. Bisphenol A has been associated with serious health effects in humans. It elicits several disorders and plays a role in the pathogenesis of several tumors such as breast, ovarian, prostate and colorectal cancer. The aim of the research is to review the latest literature assessing participation of BPA in the process of neoplasia. There is not much research on this subject and the role of BPA in the carcinogenesis is still not understood. The present review summarizes the current knowledge of the role of BPA in carcinogenesis.
REFERENCES (28)
1.
Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ. Direct measurement of bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 2016; 12: 50.
2.
Chen D, Kannan K, Tan H, Zheng Z, Feng YL, Wu Y, Widelka M. Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity – a review. Environ Sci Technol 2016; 50: 5438-5453.
3.
Okazaki H, Takeda S, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Ishii H, Kohro-Ikeda E, Haraguchi K, Watanabe K, Aramaki H. Bisphenol AF as an inducer of estrogen receptor beta (ERbeta): evidence for anti-estrogenic effects at higher concentrations in human breast cancer cells. Biol Pharm Bull 2017; 40: 1909-1916.
4.
Murata M, Kang JH. Bisphenol A (BPA) and cell signaling pathways. Biotechnol Adv 2018; 36: 311-327.
5.
Song H, Zhang T, Yang P, Li M, Yang Y, Wang Y, Du J, Pan K, Zhang K. Low doses of bisphenol A stimulate the proliferation of breast cancer cells via ERK1/2/ERRgamma signals. Toxicol Vitro 2015; 30: 521-528.
6.
Dairkee SH, Luciani-Torres MG, Moore DH, Goodson WH. Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells. Carcinogenesis 2013; 34: 703-712.
7.
Shafei A, Ramzy MM, Hegazy AI, Husseny AK, El-Hadary UG, Taha MM, Mosa AA. The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer. Gene 2018; 647: 235-243.
8.
Fenichel P, Chevalier N, Brucker-Davis F. Bisphenol A: an endocrine and metabolic disruptor. Ann Endocrinol 2013; 74: 211-220.
9.
Ćwiek-Ludwicka K, Ludwicki JK. Endocrine disruptors in food contact materials; is there a health threat? Rocz Panstw Zakl Hig 2014; 65: 169-177.
10.
Nakao E, Akiyama H, Kakutani A, Mizuno O, Aozasa, Y, Akai S. Levels of tetrabromobisphenol A, tribromobisphenol A, dibromobisphenol A, monobromobisphenol A, and bisphenol a in Japanese breast milk. Chem Res Toxicol 2015; 28: 722-728.
11.
Mandrup K, Boberg J, Isling LK, Christiansen S, Hass U. Low-dose effects of bisphenol A on mammary gland development in rats. Andrology 2016; 4: 673-678.
12.
Fernandez SV, Huang Y, Snider KE, Zhou Y, Pogash TJ, Russo J. Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol 2012; 41: 369-377.
13.
Clément F, Xu X, Donini C, Clément A, Omarjee S, Delay E, Treilleux I, Fervers B, Le Romancer M, Cohen P, Maguer-Satta V. Long-term exposure to bisphenol A or benzo(a)pyrene alters the fate of human mammary epithelial stem cells in response to BMP2 and BMP4, by pre-activating BMP signaling. Cell Death Differ 2017; 24: 155-166.
14.
Chapellier M, Bachelard-Cascales E, Schmidt X, Clément F, Treilleux I, Delay E, Jammot A, Ménétrier-Caux C, Pochon G, Besançon R, Voeltzel T, Caron de Fromentel C, Caux C, Blay JY, Iggo R, Maguer-Satta V. Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by over amplifying BMPR1B cell response. Stem Cell Rep 2015; 4: 239-254.
15.
Pupo M, Pisano A, Lappano R, Santolla MF, De Francesco EM, Abonante S, Rosano C, Maggiolini M. Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts. Environ Health Perspect 2012; 120: 1177-1182.
16.
LaPensee EW, LaPensee CR, Fox S, Schwemberger S, Afton S, Ben-Jonathan N. Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer Lett 2010; 28: 167-173.
17.
Seachrist DD, Bonk KW, Ho SM, Prins GS, Soto AM, Keri RA. A review of the carcinogenic potential of bisphenol A. Reprod Toxicol 2016; 59: 167-182.
18.
Chou WC, Lee PH, Tan YY, Lin HC, Yang CW, Chen KH, Chuang CY. An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells. Toxicol Vitro 2017; 41: 133-142.
19.
Wang KH, Kao AP, Chang CC, Lin TC, Kuo TC. Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells. Reprod Toxicol 2015; 58: 229-233.
20.
Ptak A, Rak-Mardyła A, Gregoraszczuk E. Cooperation of bisphenol A and leptin in inhibition of caspase-3 expression and activity in OVCAR-3 ovarian cancer cells. Toxicol Vitro 2013; 27: 1937-1943.
21.
Shi XY, Wang Z, Liu L, Feng LM, Li N, Liu S, Gao H. Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway. Chemosphere 2017; 185: 361-367.
22.
Mileva G, Baker SL, Konkle A, Bielajew C. Bisphenol-A. epigenetic reprogramming and effects on reproduction and behavior. Int J Environ Res Public Health 2014; 11: 7537-7561.
23.
Tarapore P, Ying J, Ouyang B, Burke B, Bracken B, Ho SM. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PLoS One 2014; 9: e90332.
24.
Chen ZJ, Yang XL, Liu H, Wei W, Zhang KS, Huang HB, Giesy JP, Liu HL, Du J, Wang HS. Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions. Arch Toxicol 2015; 89: 1371-1381.
25.
Shi T, Zhao C, Li Z, Zhang Q, Jin X. Bisphenol a exposure promotes the migration of NCM460 cells via estrogen receptor-mediated integrin beta1/MMP-9 pathway. Environ Toxicol 2016; 31: 799-807.
26.
Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol 2013; 42: 132-155.
27.
van der Meer T, Artacho-Cordón F, Swaab DF, Struik D, Makris KC, Wolffenbuttel BHR, Frederiksen H, van Vliet-Ostaptchouk JV. Distribution of non-persistent endocrine disruptors in two different regions of the human brain. Int J Environ Res Public Health 2017; 14. pii: E1059.
28.
Duan B, Hu X, Zhao H, Qin J, Luo J. The relationship between urinary bisphenol A levels and meningioma in Chinese adults. Int J Clin Oncol 2013; 18: 492-497.
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| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
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