REVIEW PAPER
Betulin: a natural product with promising anticancer activity
against colorectal cancer cells
1
Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland
2
Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland
3
Department of Clinic General Oncological and Endocrinological Surgery, Regional Hospital, Kielce, Poland
Submission date: 2020-12-08
Acceptance date: 2020-12-11
Publication date: 2020-12-31
Medical Studies 2020;36(4):298-302
KEYWORDS
TOPICS
ABSTRACT
Colorectal cancer is the third most frequently diagnosed type of cancer in men, while it ranks second in women. The high mortality rate of people with colorectal cancer is due to the advanced stage at diagnosis and the low selectivity of the currently used cytostatics. One of the important directions in searching for new anticancer substances is research of natural origin compounds. Betulin is a promising substance from this group, showing activity against colon cancer cells with low toxicity. Studies of betulin carried out in the aspect of the evaluation of this direction of activity concerned human tumor cell lines Col2, SW707, DLD-1, HT29 and HCT116. It was also important to determine the molecular mechanisms of action of this triterpene in colon cancer cells.
REFERENCES (23)
1.
e Matos MB, Barbosa LE, Teixeira JP. Narrative review comparing the epidemiology, characteristics, and survival in sporadic colorectal carcinoma/Lynch syndrome. J Coloproctol 2020; 40: 73-78.
2.
Kycler W, Kubiak A, Trojanowski M, Janowski J. Adenomas – genetic factors in colorectal cancer prevention. Rep Pract Oncol Radiother 2018; 23: 75-83.
3.
Wojciechowska U, Didkowska J. Zachorowania i zgony na nowotwory złośliwe w Polsce. Krajowy Rejestr Nowotworów, Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie – Państwowy Instytut Badawczy. Available online: http://onkologia.org.pl/raport... (accessed on 30 November 2020).
4.
Piechowska AM, Wawszczak M, Cedro A, Głuszek S. Suppressor genes as molecular markers of colorectal cancer – a review of the latest reports. Medical Studies 2020; 36: 35-45.
5.
Xie YH, Chen YX, Fang JY. Comprehensive review of targeted therapy for colorectal cancer. Sig Transduct Target Ther 2020; 5: 22.
6.
Skarkova V, Kralova V, Krbal L, Matouskova P, Soukup J, Rudolf E. Oxaliplatin and irinotecan induce heterogenous changes in the EMT markers of metastasizing colorectal carcinoma cells. Exp Cell Res 2018; 369: 295-303.
7.
Delasoie J, Pavic A, Voutier N, Vojnovic S, Crochet A, Nikodinovic-Runic J, Zobi F. Identification of novel potent and non-toxic anticancer, antiangiogenic and antimetastatic rhenium complexes against colorectal carcinoma. Eur J Med Chem 2020; 204: 112583-112600.
8.
Lu JJ, Wang YT. Identification of anti-cancer compounds from natural products. Chin J Nat Med 2020; 18: 481-482.
9.
Rejhová A, Opattová A, Čumová A, Slíva D, Vodička P. Natural compounds and combination therapy in colorectal cancer treatment. Eur J Med Chem 2018; 144: 582-594.
10.
Aggarwal B, Prasad S, Sung B, Krishnan S, Guha S. Prevention and treatment of colorectal cancer by natural agents from mother nature. Curr Colorectal Cancer Rep 2013; 9: 37-56.
11.
Mbaveng AT, Fotso GW, Ngnintedo D, Kuete V, Ngadjui BT, Keumedjio F, Andrae-Marobela K, Efferth T. Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells. Phytomedicine 2018; 48: 112-119.
12.
Amiri S, Dastghaib S, Ahmadi M, Mehrbod P, Khadem F, Behrouj H, Aghanoori MR, Machaj F, Ghamsari M, Rosik J, Hudecki A, Afkhami A, Hashemi M, Los MJ, Mokarram P, Madrakian T, Ghavamia S. Betulin and its derivatives as novel compounds with different pharmacological effects. Biotechnol Adv 2020; 38: 107409-107447.
13.
Bębenek E, Chodurek E, Orchel A, Dzierżewicz Z, Boryczka S. Antiproliferative activity of novel acetylenic derivatives of betulin against G-361 human melanoma cells. Acta Pol Pharm Drug Res 2015; 72: 699-703.
14.
Król SK, Kiełbus M, Rivero-Müller A, Stepulak A. Comprehensive review on betulin as a potent anticancer agent. Biomed Res Int 2015; 2015: 584189.
15.
Hwang BY, Chai HB, Kardono LBS, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic triterpenes from the twigs of Celtis philippinensis. Phytochemistry 2003; 62: 197-201.
16.
Bębenek E, Chrobak E, Wietrzyk J, Kadela M, Chrobak A, Kusz J, Książek M, Jastrzębska M, Boryczka S. Synthesis, structure and cytotoxic activity of acetylenic derivatives of betulonic and betulinic acids. J Mol Struct 2016; 1106: 210-219.
17.
Thibeault D, Gauthier C, Legault J, Bouchard J, Dufour P, Pichette A. Synthesis and structure – activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin. Bioorg Med Chem 2007; 15: 6144-6157.
18.
Rzeski W, Stepulak A, Szymański M, Juszczak M, Grabarska A, Sifringer M, Kaczor J, Kandefer-Szerszeń M. Betulin elicits anti-cancer effects in tumour primary cultures and cell lines in vitro. Basic Clin Pharmacol Toxicol 2009; 105: 425-432.
19.
Guo WB, Zhang H, Yan WQ, Liu YM, Zhou F, Cai DS, Zhang WX, Huang XM, Jia XH, Chen HS, Qi JC, Wang PL, Xu B, Lei HM. Design, synthesis, and biological evaluation of ligustrazine - betulin amino-acid/dipeptide derivatives as anti-tumor agents. Eur J Med Chem 2020; 185: 111839.
20.
Heller L, Perl V, Wiemann J, Al-Harrasi A, Csuk R. Amino(oxo)acetate moiety: a new functional group to improve the cytotoxicity of betulin derived carbamates. Bioorg Med Chem Lett 2016; 26: 2852-2854.
21.
Zhou Z, Zhu C, Cai Z, Zhao F, He L, Lou X, Qi X. Betulin induces cytochrome c release and apoptosis in colon cancer cells via NOXA. Oncol Lett 2018; 15: 7319-7327.
22.
Han YH, Mun JG, Jeon HD, Kee JY, Hong SH. Betulin inhibits lung metastasis by inducing cell cycle arrest, autophagy, and apoptosis of metastatic colorectal cancer cells. Nutrients 2020; 12: 66.
23.
Mioc M, Pavel IZ, Ghiulai R, Coricovac DE, Farcaş C, Mihali CV, Oprean C, Serafim V, Popovici RA, Dehelean CA, Shtilman MI, Tsatsakis AM, Şoica C. The cytotoxic effects of betulin-conjugated gold nanoparticles as stable formulations in normal and melanoma cells. Front Pharmacol 2018; 9: 429.
Share
RELATED ARTICLE
| eISSN: | 2300-6722 |
| ISSN: | 1899-1874 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
